When the cell's recycling stations, the lysosomes, start leaking, it can become dangerous. Toxic waste risks spreading and ...

The lysosome is a small membrane bound organelle that can be found in most animal cells. It was once thought that these little sacs were like recycling centers that could take up cellular waste ...

Lysosomes are digestive organelles of the endocytic and autophagic pathways. Increasing lysosome enzyme activities could help to clear pathological cellular waste. A recent study shows that lysosomal ...

In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed. In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, ...

For the first time, the pathway through which cells repair damaged lysosomes has been observed and described. Lysosomes are the recycling center of a cell, where molecular waste is degraded into the ...

If you had to swallow a pouch of toxins, you’d like to be certain the pouch was indestructible. Similarly, every eukaryotic cell seeks to ensure that the membranes of its many miniscule sacs called ...

I’d love to read a creepy science fiction story where people dissolve. I asked my friend Anders Omsland if that could happen. He’s a biomedical researcher at Washington State University. He told me a ...

Lysosomes require tight regulation of their pH to degrade their contents. Researchers know that V-ATPase pumps protons into these little digestive sacs, but what protein shuttles the ions back out?

The retromer complex controls protein sorting, transport, and disposal via the endolysosome system. It goes awry in neurodegenerative diseases, but how so remains unclear. Metabolism breaks down in ...

The lysosome was once thought of as the trash can of the cell, a dead-end destination where cellular debris was sent for disposal. But a growing body of research shows that this enzyme-filled vesicle ...