The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over 100 million infections and millions of deaths. Effective vaccines remain the best hope of ...

MHC-I presents viral antigens for CD8+ cytotoxic T lymphocyte (CTL) activation. Upon activation, these cells kill and eliminate virus-infected cells throughout the human body. Several viruses have ...

Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor immunity. This review synthesizes emerging mechanistic evidence showing that ...

The chicken major histocompatibility complex (MHC) represents a compact and evolutionarily distinct genomic region that plays a critical role in orchestrating adaptive immunity. Characterised by a ...

Peptides that bind major histocompatibility complex (MHC) class I molecules act as chemosensory signals in a region of the brain thought to be important in chemosensory communication, according to a ...

When early Stone Age farmers first moved into Europe from the Near East about 8,000 years ago, they met and began mixing with the existing hunter-gatherer populations. Now genome-wide studies of ...

The adaptive immune system is an antigen-specific structure that discriminates non-self molecules through the recognition of peptide antigens using receptor interactions between T-cells and ...

“Allogeneic hematopoietic stem cell transplantation is a curative therapy for hematopoietic malignant and non-malignant disease. However, the immunological complication known as graft-versus-host ...

Cancer immunotherapy using immune checkpoint blockade (ICB) agents have proven to be revolutionary in many areas of oncology. One way to improve the specificity of this therapy is the use of molecules ...